Anti-HIV Antibodies May Spur AIDS Vaccine Development

englibertm · 2013-04-11T15:48:05+00:00

Researchers report a breakthrough in generating powerful antibodies that can neutralize HIV. An HIV infection is really an intensive molecular arms race launched from the minute the virus infects a new host. AIDS progresses not because the body isnt capable of fighting off HIV it is. But the immune defenses eventually succumb to the virus in the final standoff. Now researchers, led by Barton Haynes, director of the Duke University Human Vaccine Institute at Duke University School of Medicine, believe they have found a way to tip the odds in the immune systems favor. From the moment of infection, the immune system goes on alert and immediately generates antibodies designed to attach to and destroy HIV. And for the first few weeks, these antibodies are successful, eliminating all but a few viruses that remain hidden away from the bodys surveillance systems. These viral stalwarts then mutate to escape detection and start to flourish, expanding until new antibodies are generated to dispatch them. That launches another wave of viral destruction that pushes HIV to mutate yet again, prompting another immune attack, and so on, until eventually the body isnt able to keep up with the virus and pushes out poor, or no more additional antibodies that can neutralize HIV. Illustration of HIV (Human Immunodeficiency Virus) capsids with protruding docking (gp120) and transmembrane (gp41) glycoproteins

Thread starter englibertm
Start date Apr 11, 2013

englibertm

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Anti-HIV Antibodies May Spur AIDS Vaccine Development

englibertm

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