Herbal preparations boost male, female fertility

Vikawe P · 2012-11-27T09:33:50+00:00

Herbal preparations made of plants including ginger, sweet potatoand cowhage have been shown to be effective in treating male and femaleinfertility by several clinical trials. SEVERAL studies haveshown that the number of infertile couples is on the rise or rather the numberof couples unable to achieve pregnancy at least three years after marriage. However, the WorldHealth Organisation (WHO) defines infertility as the failure to conceive afterone year of regular unprotected intercourse with the same partner. Indeed, more men arefiring blanks as a result of low sperm count and quality. The women are notfaring better. More women are shedding fewer and poor quality eggs due tohormonal and menstrual disorders. Defects in sperms areassociated with low sperm concentration (oligospermia), poor sperm motility(asthenospermia) or abnormal sperm morphology (teratospermia). These defectsare collectively called as oligoasthenoteratospermia. Menstrual disordersinclude: oligomenorrhoea is infrequent menses occurring at intervals longerthan 35 days; menorrhagia is excessive menses in amount (greater than 80 ml.blood loss per cycle) as well as duration (greater than five days);Dysfunctional Uterine Bleeding (DUB) is excessive uterine bleeding where thecause cannot be detected. Dysmenorrhoea is menstruation associated with severepain. But herbalpreparations made specifically for men and another for women have shown promisein clinical trials. A combination ofplants extracts has been demonstrated to prevent premature ejaculation, andboost sperm quality, quantity and motility. A clinical study onAddyzoa, produced by Charak Pharmaceuticals India and marketed in Nigeria byFidson Healthcare Plc, concluded that treatment with the drug is effective inimproving the semen quality by increasing the sperm count and sperm motility. Also, clinical trialof another herbal preparation marketed as M2 Tone showed that it is veryeffective in the treatment of unexplained infertility in females; and inirregular menstruation, menorrhagia, dysmenorrhoea, sterility and menopausaldisturbances such as leg cramps, irritability, lack of concentration, hotflushes. M2 Tone syrup is aherbo-mineral formulation blended with 47 natural chemically activeingredients, known for their efficacy in various gynaecological conditions. Addyzoa is made ofplants such as Emblica officinalis (Phyllanthus embilica), Withania somnifera,Tinospora cordifolia, Asparagus racemosus, Chlorophytum tuberosum, Mucunapruriens, Sida cordifolia, and Ipomoea digitata. While M2 Tone is madeup of plants such as Andropogon muricatus,Cuminum cyminum, Zingiber officinale,Caryophyllus aromaticus, Piper cubeba, Bombax malabaricum, Symplocos racemosa,Bryonia laciniosa, Terminalia chebula, Ficus bengalensis,, and Asparugasracemosus. Zingiber officinaleis commonly called ginger. It is of plant family Zingiberaceae. Ipomoea digitata,commonly called sweet potato, belongs to the plant family Convolvulaceae. Mucuna pruriens iscommonly called cowhage or velvet bean. It is known as werepe in Yoruba andagbala or agboloko in Ibo. The velvet bean plant is notorious for the spikyhairs on the mature bean pods that are very irritating to the skin. Tinospora cordifoliais a plant that belongs to the menispermaceae family. The common names of theplant include hearth leaves and moon seed. It is called epa ikun in Yoruba. Chroropphytumtuberosum belongs to Anthericaceae family. It is called albasar kwadi in Hausa. Asparagus racemosusbelongs to the plant family Asparagaceae. The plant grows throughout thetropical and subtropical parts of India up to an altitude of 1500 metre. Withania somniferabelongs to the family Solanaceae. It is called burrwood, horse root, Wintercherry in English. It is called karama anta in Hausa. Sida cordifolia(bala, country mallow, heart-leaf sida or flannel weed) is a perennialsub-shrub of the mallow family Malvaceae. Phyllanthus emblica(syn. Emblica officinalis), the Indian gooseberry, or aamla, is a deciduoustree of the Phyllanthaceae family. It is known for its edible fruit of the samename. The clinical study onM2 Tone was conducted on 50 women of unexplained infertility at the finalcount. 50 per cent each were administered M2 Tone syrup and placebo toscientifically reassess efficacy at primary level. M2 Tone is alsomarketed in Nigeria by Fidson Healthcare Plc. The results of theclinical trials published in Obstetrics & Gynaecology showed 33.3 per centconception rate with full safety in M2 Tone group, even though the duration ofthe trial was short, nine months. One conception was reported in the patientson placebo. Additionally, in 36.3 per cent women, M2 Tone cured menstrualirregularities. All the women with menorrhagia and hypomenorrhoea and 75 percent with spasmodic dysmenorrhoea responded favourably. The mechanism by whichM2 Tone acts is by its proven estrogenic effect on the female reproductivesystem, either directly or through pituitary gonadotropins, as also by itsantioxytocic activity. Another study titledRole of an Ayurvedic Formulation M2-T0NE in Gynaecological Disorders andpublished The Antiseptic A Monthly Journal of Medicine and Surgery concluded:A short term clinical study using M2-TONE syrup was undertaken on 100 patientssuffering from DUB, vaginal white discharge, menstrual irregularities,dysmenorrhoea, delayed puberty, sterility, menopausal syndrome. Immediateresponse seems encouraging in patients from irregular cycles, dysmenorrhoea,DUB, vaginal discharge, menopausal syndrome and raise hopes in sterility. Researchers have alsofound that M2 Tone could be successfully used to enhance implantation AssistedReproductive Technology (ART)/ In Vitro Fertilisation (IVF). Meanwhile, adouble-blind, randomised controlled trial was planned to evaluate the efficacyof an antioxidant herbo-mineral formulation, Addyzoa in oligoasthenospermia incomparison with Ubiquinone published recently in Phytopharmacology &Therapeutic Values III concluded: Treatment with Addyzoa is effective inimproving the semen quality by increasing the sperm count and enhancing spermmotility and morphology. Treatment withAddyzoa resulted in a larger increase in sperm count as compared to Ubiquinone,though the difference was not statistically significant. In addition, asignificant increase of 1.5 to 2 times in motility was observed with Addyzoaand Ubiquinone treatment. Improvement in morphology was also observed in bothgroups. Thus, Addyzoa is a better option for treating male infertility as italso provides an advantage over Ubiquinone in terms of cost of therapy. Furthertrials in a larger number of patients are required to corroborate the findingsof this study. In previous studies,the efficacy and safety of Addyzoa in improving seminal parameters has beenstudied extensively. The effect of six months therapy with Addyzoa on spermparameters was investigated in a randomized, placebo-controlled study of 200men with idiopathic subfertility. The results indicatedthat Addyzoa resulted in statistically significant improvements in spermdensity (368 per cent), motility (197 per cent) and morphology (183 per cent)as well as other routine sperm tests. Pregnancy rates among the subfertilecouples, to which these men belonged, were found to be 25 per cent with Addyzoaover a two-year follow-up period as compared to two per cent with placebo. The effects ofAddyzoa on male factor subfertility have also been compared with clomiphenecitrate. In a six-month, randomized study of Addyzoa in 100 men in comparisonwith clomiphene, treatment with Addyzoa resulted in statistically significantimprovements in sperm density, motility, morphology as well as other routinesperm tests.

Thread starter Vikawe P
Start date Nov 27, 2012

Vikawe P

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Nov 27, 2012

Ilonga Msalabani

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Herbal preparations boost male, female fertility

Vikawe P

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Ilonga Msalabani

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